N-Hydroxyl derivatives of guanidine based drugs as enzymatic NO donors

…, Z Zheng, JJ Galligan, DL Kreulen, PG Wang

Index: Xian, Ming; Li, Xiaopeng; Tang, Xiaoping; Chen, Xinchao; Zheng, Zhongling; Galligan, James J; Kreulen, David L; Wang, Peng G Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 17 p. 2377 - 2380

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Citation Number: 21

Abstract

Recent research suggests that NO may play a role in the physiological effects of some guanidine-containing drugs. In this report, three guanidine-containing drugs (guanadrel, guanoxan, and guanethidine) together with their N-hydroxyl derivatives were synthesized and their NO-releasing abilities catalyzed by nitric oxide synthases (NOSs) and horseradish peroxidase were evaluated. The guanidine containing compounds could not release NO ...