Studies on anti-Helicobacter pylori agents. Part 1: Benzyloxyisoquinoline derivatives

…, D Barrett, H Azami, C Morinaga, S Matsumoto…

Index: Yoshida, Yoshiki; Barrett, David; Azami, Hidenori; Morinaga, Chizu; Matsumoto, Satoru; Matsumoto, Yoshimi; Takasugi, Hisashi Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 11 p. 2647 - 2666

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Citation Number: 34

Abstract

The synthesis and optimization of the anti-Helicobacter pylori activity of a novel series of benzyloxyisoquinoline derivatives that was discovered by a random screening process, are described. In the in vitro assay, compound 10c containing a 3-acetamido-2, 6-dichlorobenzyl substituent was found to have extremely potent activity against H. pylori and no activity against other common bacteria. The anti-H. pylori activity of 10c was superior to that of ...

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