Synthesis of some pyridylamino??1, 4??disubstituted phthalazines

DV Bautista, G Bullock, FW Hartstock…

Index: Bautista, Dorothy V.; Bullock, Graham; Hartstock, Frederick W.; Thompson, Laurence K. Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 345 - 347

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Citation Number: 13

Abstract

Abstract Two general procedures involving the condensation of phthalonitrile or 1, 3- diiminoisoindoline with various aminopicolines, followed by ring expansion with hydrazine to the corresponding phthalazine are described. Syntheses are reported of 1, 4-di (3′- methyl-2′-pyridyl) aminophthalazine, 1, 4-di (5′-methyl-2′-pyridyl) aminophthalazine, and 1, 4-di (4′, 6′-dimethyl-2′-pyridyl) aminophthalazine.