Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogs of 1, 2, 3, 5-tetrahydro-2-oxoimidazo [2, 1-b] …

MC Venuti, RA Stephenson, R Alvarez…

Index: Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M. Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2136 - 2145

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Citation Number: 109

Abstract

Hybridization of structural elements of 1, 2, 3, 5-tetrahydro-2-oxoimidazo [ 2, l-blquinazoline ring system common to the cyclic AMP (CAMP) phosphodiesterase (PDE) inhibitors lixazinone (RS-82856, I) and anagrelide (3) with complementary features of other PDE inhibitor cardiotonic agents prompted the design and synthesis of the title compounds 7a-d, 11, 12, and 13a, b. The necessary features of these compounds were determined within ...