First chiral synthesis of the N-terminal amino acid congener of nikkomycin Z based on lipase-catalyzed enantioselective acetylation of a primary alcohol possessing …

H Akita, Y Takano, K Nedu, K Kato

Index: Akita, Hiroyuki; Takano, Yoshiki; Nedu, Katsushi; Kato, Keisuke Tetrahedron Asymmetry, 2006 , vol. 17, # 11 p. 1705 - 1714

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Citation Number: 6

Abstract

A stereoselective synthesis of a versatile chiral synthon possessing two stereogenic centers,(2S, 3S)-3-[2-(5-benzyloxypyridyl)]-2-methyl-1, 3-propane diol 12 (> 99% ee), was achieved by using a chemo-enzymatic method. The conversion of (2S, 3S)-12 to the ...