Convenient preparation of dimethyl (trifluoromethyl) malonate and related compounds.

N Ishikawa, T Yokozawa

Index: Ishikawa, Nobuo; Yokozawa, Tsutomu Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 3 p. 724 - 726

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Citation Number: 38

Abstract

The preparative method for dimethyl (trifluoromethyl) malonate (4) from the adduct of perfluoro-2-methylpropene with methanol was improved, and several reactions of this base- sensitive substance were investigated. Alkylation of 4 was achieved by using CsF as a condensing agent, and the Michael addition on vinyl ketones proceeded in triethylamine– pyridine medium.