Inorganica Chimica Acta

Dinuclear zinc bis (thiosemicarbazone) complexes: Synthesis, in vitro anticancer activity, cellular uptake and DNA interaction study

D Palanimuthu, AG Samuelson

Index: Palanimuthu, Duraippandi; Samuelson, Ashoka G. Inorganica Chimica Acta, 2013 , vol. 408, p. 152 - 161

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Citation Number: 14

Abstract

Abstract Four dinucleating bis (thiosemicarbazone) ligands and their zinc complexes have been synthesized and characterized by multinuclear NMR (1 H and 13 C), IR, UV–Vis, ESI- MS and fluorescence spectroscopic techniques. Their purity was assessed by elemental analysis. Cytotoxicity was tested against five human cancer cell lines using the sulphorhodamine B (SRB) assay, where one of the complexes, 1, 3-bis {biacetyl-2′-(4 ″ ...