Asymmetric synthesis of homoproline derivatives via Rh (I)-catalyzed hydrogenation using chiral bisphosphines as ligands

YJ Zhang, JH Park, S Lee

Index: Zhang, Yong Jian; Park, Jung Hwan; Lee, Sang-Gi Tetrahedron Asymmetry, 2004 , vol. 15, # 14 p. 2209 - 2212

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Citation Number: 27

Abstract

It has been demonstrated for the first time that Rh (I)-catalyzed asymmetric hydrogenation of cyclic β-enamino acid derivatives 1 using chiral bisphosphines could be a highly efficient synthetic method for optically active homoproline derivatives. The enantioselectivity and conversion yield were largely dependent upon the chiral ligand. Using the Me-BDPMI forming a seven-membered metal chelate, the N-acetylated β-enamino acid methyl ester ...