New calcineurin inhibiting 3??dimethylaminopropyl substituted diarylheterocycles by sonogashira reactions and catalytic hydrogenation

L Yin, J Liebscher, F Erdmann

Index: Yin, Lunxiang; Erdmann, Frank; Liebscher, Juergen Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 7 p. 1369 - 1379

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Citation Number: 18

Abstract

Abstract A series of calcineurin inhibiting compounds 1 consisting of a central aromatic N- heterocycle, two aryl substituents and a 3-dimethylaminopropyl chain was synthesized by introduction of the side chain. A corresponding haloheterocycle 3 was transformed into a 3- dimethylaminopropynylheterocycle 2 by Sonogashira coupling and was in turn hydrogenated in the presence of Pd/C to afford the 3-dimethylaminopropyl-sub-stiuted ...