Regio??and Stereoselective Dirhodium (II)??Catalysed Intramolecular C− H Insertion Reactions of α??Diazo?螃窿?(dialkoxyphosphoryl) acetamides and??acetates

PMP Gois, CAM Afonso

Index: Gois, Pedro M. P.; Afonso, Carlos A. M. European Journal of Organic Chemistry, 2003 , # 19 p. 3798 - 3810

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Citation Number: 48

Abstract

Abstract α-Diazo-α-(dialkoxyphosphoryl) acetates and-acetamides afforded α- (dialkoxyphosphoryl) lactones and lactams, respectively, in moderate to high yields through dirhodium (II)-catalysed intramolecular carbon− hydrogen insertion reactions. In the case of α-diazo-α-(dialkoxyphosphoryl) acetamides a remarkable preference for the formation of γ- lactam was observed, with stereocontrol in favour of the trans diastereomer.(© Wiley-VCH ...