Synthesis and activities of new arylsulfonamido thromboxane A 2 receptor antagonists

…, JM Teulon, F Caussade, A Virone-Oddos…

Index: Sartori, E.; Camy, F.; Teulon, J. M.; Caussade, F.; Virone-Oddos, A.; Cloarec, A. European Journal of Medicinal Chemistry, 1993 , vol. 28, # 7-8 p. 625 - 632

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Citation Number: 5

Abstract

Abstract New benzoic, benzeneacetic and thiazole-4-acetic acids bearing an arylsulfonamido alkyl or alkylhetero side chain were synthesized and tested in vitro for affinity for human platelet thromboxane A 2 receptors and inhibition of U46619-induced rat aortic ring contraction. Influence of substitution patterns, chain length and presence of heteroatoms were studied and compounds within a 30 nmol range for inhibition of ...