The Journal of Organic Chemistry

ESR spin-trapping study of the thermal decomposition of N-pivaloxyacetanilides in benzene

M Novak, BA Brodeur

Index: Novak, Michael; Brodeur, Brenda A. Journal of Organic Chemistry, 1984 , vol. 49, # 6 p. 1142 - 1144

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Citation Number: 33

Abstract

Summary: Spin-trapping results favor a mechanism in- volving homolytic cleavage of the N-0 bond for the thermal decomposition in benzene of N-pivaloxyacet- anilides, which are models for carcinogenic metabolites of aromatic amides. ... Sir: Sulfuric and carboxylic acid esters of N-hydroxy-N- arylacetamides are important carcinogenic metabolites derived from polycyclic N-arylacetamides including N- acetyl-2-aminofl~orene.~~~ Although dismutation ...