Synthesis of difurfuryl diamines by the acidic condensation of furfurylamine with aldehydes and their mechanism of formation

MS Holfinger, AH Conner, DR Holm…

Index: Holfinger; Conner; Holm; Hill Jr. Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1595 - 1598

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Citation Number: 21

Abstract

Difurfuryl diamino compounds can be obtained via single-step reactions of furfurylamine with formaldehyde and other aldehydes in 2.5-5.2 M hydrochloric acid at 20-50" C. Yields for the single step reaction (30-50%) are comparable to those for three-step procedures involving protection and deprotection of the amino group.