4-(1, 2, 5, 6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: A novel class of compounds with central dopamine agonist properties

JC Jaen, LD Wise, BW Caprathe, H Tecle…

Index: Jaen, Juan C.; Wise, Lawrence D.; Caprathe, Bradley W.; Tecle, Haile; Bergmeier, Stephen; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 311 - 317

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Citation Number: 179

Abstract

Jaen et al. and by their ability to reverse the y-butyrolactone (GBL) induced increase in the rate of dihydroxyphenylalanine (DOPA) synthesis (an indirect measure of the rate of DA synthesis) in the rat corpus striatum, a major brain DA projection area. 13 Inhibition of exploratory locomotor activity in mice and rats was used as a behavioral index of DA autoreceptor acti~ ation'~ and/or postsynaptic DA antag0ni~ ml~ As part of this test, ...