Synthesis of and Analysis of Thiol Additions to. beta.-Alkyl-. alpha.,. beta.-unsaturated Trifluoromethyl Ketones

RJ Linderman, EA Jamois…

Index: Linderman, Russell J.; Jamois, Eric A.; Tennyson, Scott D. Journal of Organic Chemistry, 1994 , vol. 59, # 5 p. 957 - 962

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Citation Number: 34

Abstract

A series of &alkyl-a, &unsaturated trifluoromethyl ketones have been prepared from the corresponding a-acetylenic trifluoromethyl ketones. The addition of sulfur nucleophiles was shown by chemical and lgF NMR studies to proceed exclusively by 1, 4-addition with no indication of any 1, a-addition products. The unsaturated trifluoromethyl ketones have been shown to be effective inhibitors of rat cytosolic glutathione-S-transferase#

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