Synthesis, chemistry and photochemical substitutions of 6, 11-dihydro-5H-pyrrolo [2, 1-b][3] benzazepin-11-ones

Y Girard, JG Atkinson, PC Belanger…

Index: Girard; Atkinson; Belanger; et al. Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3220 - 3234

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Citation Number: 65

Abstract

A series of 6, 11-dihydro-5H-pyrrolo [2, 1-b][3] benzazepin-ll-ones, 4, has been prepared as intermediates for potential CNS drugs. Substituents in the pyrrole ring of 4 were introduced by Friedel-Crafts cyclization of pyrrole-substituted l-(2-phenethyl) pyrrole-2-carboxylic acid derivatives (6) and by electrophilic substitution on the parent ketone 4a. Substituents in the benzene ring of 4 were introduced by Friedel-Crafts cyclization of substituted 2-(2-pyrrol-l- ...

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