Tetrahedron letters

Stereoselective acyl transfer reactions controlled by the diphenylphosphinoyl group: X-ray structures of stable crystalline silylated tetrahedral intermediates

N Feeder, G Hutton, S Warren

Index: Feeder, Neil; Hutton, Gordon; Warren, Stuart Tetrahedron Letters, 1994 , vol. 35, # 32 p. 5911 - 5914

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Citation Number: 15

Abstract

Abstract Acyl transfer with LDA on benzoates of single diastereoisomers of 3- hydroxyalkyldiphenylphosphine oxides in the presence of trimethylsilyl chloride gives silylated tetrahedral intermediates in carbonyl displacement reactions with the stereochemically controlled creation of two new chiral centres. X-rays reveal the stereochemistry.