Pd-catalyzed regioselective hydroarylation of α-(2-aminoaryl)-α, β-ynones with organoboron derivatives as a tool for the synthesis of quinolines: experimental …

A Arcadi, M Aschi, F Marinelli, M Verdecchia

Index: Arcadi, Antonio; Aschi, Massimiliano; Marinelli, Fabio; Verdecchia, Mirella Tetrahedron, 2008 , vol. 64, # 22 p. 5354 - 5361

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Citation Number: 38

Abstract

The Pd-catalyzed hydroarylation of β-(2-aminoaryl)-α, β-ynones with organoboron derivatives, leading to 2, 4-diarylquinolines in good to excellent yields through sequential cycloamination, has been investigated. The reaction is catalyzed by both Pd (II) and Pd (0) precatalysts, and can be carried out even under neutral conditions. The regiochemical outcome is inverted with respect to the Pd-catalyzed hydroarylation of β-(2-aminoaryl)-α, β ...