Heterocyclic analogs of chlorcyclizine with potent hypolipidemic activity

…, D Riddell, J Salmon, GVW Stevenson

Index: Ashton, Michael J.; Ashford, Alan; Loveless, Anthony H.; Riddell, David; Salmon, John; Stevenson, Gregory V.W. Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1245 - 1253

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Citation Number: 26

Abstract

Pharmacol. 1970, 19, 1463. was discovered during our search for novel hypolipidemic agents that the isothiazole cyclizine analogues 3 and 4 significantly reduced the concentration of serum cholesterol and triglycerides in the serum of rats. However, compounds 3 and 4 were considered to lack sufficient potency to warrant further investigation. We subsequently prepared and evaluated a number of analogues of these ...