Sequential Reductive Amination??Hydrogenolysis: A One??Pot Synthesis of Challenging Chiral Primary Amines

…, DE Negru, M El??Shazly, D Hu, A Sadiq…

Index: Nugent, Thomas C.; Negru, Daniela E.; El-Shazly, Mohamed; Hu, Dan; Sadiq, Abdul; Bibi, Ahtaram; Umar, M. Naveed Advanced Synthesis and Catalysis, 2011 , vol. 353, # 11-12 p. 2085 - 2092

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Citation Number: 18

Abstract

Abstract Difficult-to-access chiral primary amines were formed in good to high yield and ee using a rare example of a one-pot synthesis from prochiral ketones (sequential reductive amination-hydrogenloysis). As a highlight we also demonstrate a one-pot reductive amination-hydrogenolysis-reductive amination (five reactions) of ortho- methoxyacetophenone resulting in the chiral diamine 1-(2-methoxyphenyl) ethyl-(2- ...