SYNTHESIS BIODISTRIBUTION AND QSAR STUDIES OF FIVE Tc-99M LABELED NOVEL N3S PSEUDO-PEPTIDE COMPLEXES

H Zhang, H Ye, Y Zhang, X Zheng, J Han, H Li…

Index: Zhang, Hua-Bei; Ye, Hai-Hong; Zhang, Ya-Ling; Zheng, Xuefang; Han, Jian-Sheng; Li, Hua; Liu, Chun-Ping Medicinal Chemistry Research, 2005 , vol. 14, # 1 p. 40 - 56

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Citation Number: 4

Abstract

Abstract Five novel N3S pseudo-peptide chelators derived from mercaptoacetic acid have been synthesized and characterized based on the spectroscopic data. All the chelators were labeled with Technicium-99m to evaluate their biological activities. Investigations of their biodistribution in mice showed all five pseudo-peptide chelators (MGQ, MGGQ, MAGQ, MVGQ, MFGQ) are rapidly cleared from blood, mainly through renal clearance. 99mTc- ...