A novel synthesis of the 2-aminoimidazol-4-carbaldehyde derivatives, versatile synthetic intermediates for 2-aminoimidazole alkaloids

N Ando, S Terashima

Index: Ando, Naoki; Terashima, Shiro Synlett, 2006 , # 17 p. 2836 - 2840

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Citation Number: 15

Abstract

Abstract The title synthesis was achieved by the reaction of t-butoxycarbonylguanidine with 3-bromo-1, 1-dimethoxypropan-2-one as a key step. Starting with 1-tert-butoxycarbonyl-2- tert-butoxycarbonylaminoimidazol-4-carbaldehyde thus obtained expeditious synthesis of oroidin, hymenidin, dispacamide and monobromodispacamide, the representative 2- aminoimidazole alkaloids, was accomplished.