Design, synthesis and antitumor activity of a series of novel coumarin–stilbenes hybrids, the 3-arylcoumarins

CF Xiao, LY Tao, HY Sun, W Wei, Y Chen, LW Fu…

Index: Xiao, Chun Fen; Tao, Li Yang; Sun, Hong Yi; Wei, Wen; Chen, Yu; Fu, Li Wu; Zou, Yong Chinese Chemical Letters, 2010 , vol. 21, # 11 p. 1295 - 1298

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Citation Number: 15

Abstract

A series of novel coumarin–stilbenes hybrids called 3-arylcoumarins were synthesized via Perkin reaction and evaluated as potential antitumor agents. The results showed that some compounds exhibited in vitro activity against KB, KV, MCF-7, MCF-7/ADR cell lines to some extent. Compound 3a showed remarkable effect against KB tumor cells with an IC50 value of 5.18 μmol/L.