Improved Synthesis of β-D-6-Methylpurine Riboside and Antitumor Effects of the β-D-and α-D-Anomers

C Marasco, P Pera, A Spiess, R Bernacki, J Sufrin

Index: Marasco Jr., Canio J.; Pera, Paula J.; Spiess, Arthur J.; Bernacki, Ralph; Sufrin, Janice R. Molecules, 2005 , vol. 10, # 8 p. 1015 - 1020

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Citation Number: 8

Abstract

Abstract: 6-Methylpurine-β-D-riboside (β-D-MPR) has been synthesized by coupling 6- methylpurine and 1-O-acetyl-2, 3, 5-tri-O-benzoyl-D-ribose using conditions that produce the β-D-anomer exclusively. The in vitro antitumor effects of β-D-MPR and 6-methyl-purine-α-D- riboside (α-D-MPR) in five human tumor cell lines showed that β-D-MPR was highly active (IC 50 values ranging from 6 to 34 nM). α-D-MPR, although less active than β-D-MPR, ...