Design and synthesis of new prostaglandin D 2 receptor antagonists

…, Y Okada, R Matsumoto, F Nambu, H Nakai…

Index: Iwahashi, Maki; Takahashi, Eiji; Tanaka, Motoyuki; Matsunaga, Yoko; Okada, Yutaka; Matsumoto, Ryoji; Nambu, Fumio; Nakai, Hisao; Toda, Masaaki Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5361 - 5371

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Citation Number: 3

Abstract

To identify new cost-effective prostaglandin D2 (DP) receptor antagonists, a series of novel 3- benzoylaminophenylacetic acids were synthesized and biologically evaluated. Among those tested, some representative compounds were found to be orally available. Receptor selectivity and rat PK profiles were also evaluated. The structure–activity relationship (SAR) study is presented.