Tetrahedron Letters

YbCl 3-catalyzed one-pot synthesis of dihydropyrazines, piperazines, and pyrazines

L Fan, W Chen, C Qian

Index: Fan, Liyan; Chen, Wen; Qian, Changtao Tetrahedron Letters, 2013 , vol. 54, # 3 p. 231 - 234

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Citation Number: 8

Abstract

A simple and efficient synthetic approach to dihydropyrazines via YbCl3-catalyzed reaction of α-hydroxyketones with diamines under mild conditions was developed. The corresponding 2, 3-subsitituted piperazines and pyrazines were obtained through tandem conversion of dihydropyrazines with good yields.

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