Journal of fluorine chemistry

A facile one-pot preparation of 2-methyl-and 2-phenyl-4-fluoro-5-trifluoromethyl-6-methoxypyrimidine from methyl 2-hydryl-2-(F-methyl)-F-propyl ether

Y Inouye, Y Higuchi

Index: Inouye,Y.; Higuchi,Y. Journal of Fluorine Chemistry, 1985 , vol. 27, p. 231

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Citation Number: 6

Abstract

The title comoounds were readily prepared in one-pot by phase-transfer reaction of a methanol adduct of 2-(z-methyl)-E- propene with acetamidine or benzamidine in the presence of aqueous sodium hydroxide in CH2C12. Various 5-trifluoromethyl- pyrimidines were also synthesized & ... OS the 4-fluorine of the title compounds. ... There is increasing interest in organic compounds bearing the trifluoromethyl group, because of their possible physiological activities as well ...