Facile synthesis of platelet-activating factor and racemic analogs containing unsaturation in the sn-1-alkyl chain

…, JT O'Flaherty, WL Salzer, MJ Thomas…

Index: Surles; Wykle; O'Flaherty; Salzer; Thomas; Snyder; Piantadosi Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 73 - 78

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Citation Number: 52

Abstract

2, R= palmitoleyl 4. R. oleyl 5, R= linoleyl leukocyte-dependent release of a soluble factor from the sensitized leukocyte that reacted with platelets, resulting in the release of vasoactive amines. 2b Benveniste et al. determined that the antibody involved was of the IgE type, described the methodology for isolation of the soluble factor, and named it platelet- activating factora3 The correct chemical structure of PAF as 1-0-alkyl-2-acetyl-sn-glycero- ...