Syntheses and complement inhibitory activities of 4-(2-phenyl-1H-indol-3-yl) cyclohexane-1-carboxylic acids

…, GD DeGrazia, EJ Alexander, RG Powles…

Index: Bailey; DeGrazia; Alexander; Powles; Johnson; Patrick; Heerdt; Fairbain; Pruden Journal of Medicinal Chemistry, 1985 , vol. 28, # 2 p. 160 - 164

Full Text: HTML

Citation Number: 5

Abstract

The potential utility for drugs that inhibit complement dependent acute inflammatory events in diseases such as rheumatoid arthritiq2 lupus erythemato~ us,~ and glomerulonephritis4 has been well documented. Although many chemicals, including several antiinflammatory agents, have been reported to be inhibitory of the complement cascade in~ itro,~ none has been shown to display clinical efficacy via this mechanism. Thus, with clear relevance to ...