New methodology for conjugate additions of allylic ligands to. alpha.,. beta.-unsaturated ketones: synthetic and spectroscopic studies

BH Lipshutz, EL Ellsworth, SH Dimock…

Index: Lipshutz, Bruce H.; Ellsworth, Edmund L.; Dimock, Stuart H.; Smith, Robin A.J. Journal of the American Chemical Society, 1990 , vol. 112, # 11 p. 4404 - 4410

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Citation Number: 101

Abstract

Abstract Michael additions of allylic ligands, including allyl, methallyl, crotyl, and prenyl systems, to a variety of a, &unsaturated ketones can be effected in synthetically useful yields with allylcopper reagents in the presence of trimethylchlorosilane. Low-temperature 13C NMR spectral studies suggest that the allylic ligands are o-bound to copper.

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