Improved synthesis of thiofluorescein

…, AV Konstantinova, VN Berezhnaya…

Index: Russkikh; Konstantinova; Berezhnaya; Gerasimova; Shelkovnikov Russian Journal of Organic Chemistry, 2005 , vol. 41, # 1 p. 57 - 60

Full Text: HTML

Citation Number: 6

Abstract

Abstract Thiofluorescein was synthesized in a preparative yield by successive demethylation of 3, 3′-dimethoxydiphenyl sulfide to 3, 3′-dihydroxydiphenyl sulfide and condensation of the latter with phthalic anhydride in H 2 SO 4. The title compound was also obtained in a higher yield from 3, 3′-dimethoxydiphenyl sulfide directly in a one-pot process combining the condensation in H 2 SO 4 and demethylation in 2 Py· H 2 SO 4.