Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-one as analgesic, anti-inflammatory agents

V Alagarsamy, VR Solomon, K Dhanabal

Index: Alagarsamy; Raja Solomon; Dhanabal Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 235 - 241

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Citation Number: 157

Abstract

A variety of novel 3-phenyl-2-substituted-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-phenyl-3H-quinazolin-4-one with different aldehydes and ketones. The starting material 2-hydrazino-3-phenyl-3H-quinazolin-4-one was synthesized from aniline. The title compounds were investigated for analgesic, anti- inflammatory and ulcerogenic index activities. While the test compounds exhibited ...