Development of metal-chelating inhibitors for the Class II fructose 1, 6-bisphosphate (FBP) aldolase

…, AP Krismanich, S de Groot, T Rasmusson…

Index: Labbe, Genevieve; Krismanich, Anthony P.; De Groot, Sarah; Rasmusson, Timothy; Shang, Muhong; Brown, Matthew D.R.; Dmitrienko, Gary I.; Guillemette, J. Guy Journal of Inorganic Biochemistry, 2012 , vol. 112, p. 49 - 58

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Citation Number: 14

Abstract

It has long been suggested that the essential and ubiquitous enzyme fructose 1, 6- bisphosphate (FBP) aldolase could be a good drug target against bacteria and fungi, since lower organisms possess a metal-dependant (Class II) FBP aldolase, as opposed to higher organisms which possess a Schiff-base forming (Class I) FBP aldolase. We have tested the capacity of derivatives of the metal-chelating compound dipicolinic acid (DPA), as well a ...