Tetrahedron: Asymmetry

A chemoenzymatic synthesis of both enantiomers of 2-phenyl-3-hydroxypropylcarbamate, a metabolite of felbamate

B Morgan, G Bydlinsky, DR Dodds

Index: Morgan, Brian; Bydlinsky, Greg; Dodds, David R. Tetrahedron: Asymmetry, 1995 , vol. 6, # 7 p. 1765 - 1772

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Citation Number: 6

Abstract

PPL catalyzed desymmetrization of 2-phenyl-1, 3-propanediol (3) was the key step in the chemoenzymatic synthesis of both enantiomers of 2-phenyl-3-hydroxypropylcarbamate (2). Unsuccessful attempts at enzyme catalyzed (PPL, Novo SP435) transcarbamoylation, aminolysis and ammonolysis are also described.

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