An efficient one-pot synthesis of coumarins mediated by propylphosphonic anhydride (T3P) via the Perkin condensation

JK Augustine, A Bombrun, B Ramappa, C Boodappa

Index: Augustine, John Kallikat; Bombrun, Agnes; Ramappa, Balakrishna; Boodappa, Chandrakantha Tetrahedron Letters, 2012 , vol. 53, # 33 p. 4422 - 4425

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Citation Number: 37

Abstract

Coumarins can be synthesized by one of such methods as the Witting reaction, Perkin reaction, Pechmann reaction as well as the Knoevenagel condensation. 11 The classical Perkin condensation is perhaps the most direct and simple method known for the preparation of substituted coumarins. 12 While this procedure is a suitable method, it suffers from drawbacks such as limited substrate scope, the use of strong acids and sometimes the necessity of multi-step ...