Organic letters

Diastereoselective Synthesis of P-Stereogenic Heterocycles via Enyne Ring-Closing Metathesis

JS Harvey, GT Giuffredi, V Gouverneur

Index: Dunne, Katherine S.; Bisaro, Fabrice; Odell, Barbara; Paris, Jean-Marc; Gouverneur, Veronique Journal of Organic Chemistry, 2005 , vol. 70, # 26 p. 10803 - 10809

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Citation Number: 18

Abstract

A range of P-containing ene-diynes suitable for desymmetrization was prepared via a two- step process starting from phosphorus oxychloride. In the presence of the Hoveyda− Grubbs II catalyst, these substrates underwent diastereoselective enyne ring-closing metathesis