Cyclopropanation of alkenes with CH 2 I 2/Et 3 Al by the phase-vanishing method based on fluorous phase screen

H Matsubara, M Tsukida, S Yasuda, I Ryu

Index: Matsubara, Hiroshi; Tsukida, Masaaki; Yasuda, Shinji; Ryu, Ilhyong Journal of Fluorine Chemistry, 2008 , vol. 129, # 10 p. 951 - 954

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Citation Number: 13

Abstract

Phase-vanishing (PV) method using perfluorohexanes as a screen phase was applied to cyclopropanation reactions with CH2I2/Et2Zn and CH2I2/Et3Al. When Et3Al was used as a carbenoid generator, the reaction proceeded smoothly and desired cyclopropane derivatives were obtained in high yield. The PV cyclopropanation took 2 or 3 days to complete, however, reduction of reaction time by a factor of 2–3 was also achieved by ...