Biological evaluation of isoegomaketone isolated from Perilla frutescens and its synthetic derivatives as anti-inflammatory agents

…, CH Jin, DS Choi, MW Byun, IY Jeong

Index: Park, Yong Dae; Jin, Chang Hyun; Choi, Dae Seong; Byun, Myung-Woo; Jeong, Il Yun Archives of Pharmacal Research, 2011 , vol. 34, # 8 p. 1277 - 1282

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Citation Number: 18

Abstract

Abstract The anti-inflammatory activities of a prepared isoegomaketone 3a and its derivatives 3b–3f were evaluated in RAW 264.7 cells. Among these, the compound 3d was displayed the most potent inhibitory activities against production of nitric oxide, monocyte chemoattractant protein-1 and interleukin-6. Based on these results, the abilities of compounds 3a–3f to modulate NF-κB and AP-1-mediated gene transcription using a ...

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