Synthesis, characterization and antiamoebic activity of some hydrazone and azole derivatives bearing pyridyl moiety as a promising heterocyclic scaffold

SM Siddiqui, A Salahuddin, A Azam

Index: Siddiqui, Shadab Miyan; Salahuddin, Attar; Azam, Amir European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 411 - 416

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Citation Number: 31

Abstract

In an effort to develop effective antiamoebic agents, some hydrazones and azoles containing pyridyl moiety were synthesized and screened for in vitro antiamoebic activity against HM1: IMSS strain of Entamoeba histolytica. Among all the compounds, only five compounds (1, 3, 5, 9 and 11) were found to be better inhibitors of growth of E. histolytica than the reference drug metronidazole. The cytotoxic studies of these compounds on ...