Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics

Y Hirose, K Watanabe, A Minami, T Nakamura…

Index: Hirose, Yuki; Watanabe, Kenji; Minami, Atsushi; Nakamura, Takemichi; Oguri, Hiroki; Oikawa, Hideaki Journal of Antibiotics, 2011 , vol. 64, # 1 p. 117 - 122

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Citation Number: 3

Abstract

Abstract Quinomycin antibiotics, represented by echinomycin, are an important class of antitumor antibiotics. We have recently succeeded in identification of biosynthetic gene clusters of echinomycin and SW-163D, and have achieved heterologous production of echinomycin in Escherichia coli. In addition, we have engineered echinomycin non- ribosomal peptide synthetase to generate echinomycin derivatives. However, the ...