Tetrahedron letters

Aldol-cyclization reaction sequence for the synthesis of tetrahydrofurans

MA Calter, PM Sugathapala, C Zhu

Index: Calter, Michael A.; Sugathapala, Priyantha M.; Zhu, Cheng Tetrahedron Letters, 1997 , vol. 38, # 22 p. 3837 - 3840

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Citation Number: 46

Abstract

The aldol reactions of α-diazo-β-ketoesters with a variety of aldehydes produced adducts which underwent Rh (II)-catalyzed O H insertion reaction to yield highly substituted tetrahydrofurans. Alkylation and decarboxylation of these tetrahydrofurans formed a wide variety of tetrahydrofuran structures.