The Synthesis of Tenofovir and Its Analogues via Asymmetric Transfer Hydrogenation

…, QQ Wang, XX Wang, X Hu, MS Xie, GR Qu…

Index: Wang, Dong-Chao; Niu, Hong-Ying; Xie, Ming-Sheng; Qu, Gui-Rong; Wang, Hui-Xuan; Guo, Hai-Ming Organic Letters, 2014 , vol. 16, # 1 p. 262 - 265

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Citation Number: 13

Abstract

A series of tenofovir analogues with potential antiviral and immunobiologically active compounds were synthesized through an asymmetric transfer hydrogenation reaction from achiral purine derivatives. Up to 97% ee and good to excellent yields were achieved under mild conditions through short reaction steps. The present report suggests an efficient process to acquire tenofovir and its analogues.