Microwave??assisted synthesis of pyrimidine libraries

MC Bagley, DD Hughes, MC Lubinu…

Index: Bagley, Mark C.; Hughes, David D.; Taylor, Paul H. Synlett, 2003 , # 2 p. 259 - 261

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Citation Number: 48

Abstract

Abstract Di-or trisubstituted pyrimidine libraries are prepared in good yield by the microwave irradiation of an alkynone and either an amidine or guanidine at 120–150 C in acetonitrile in the presence of sodium carbonate or at 100 C after treatment with methanolic sodium methoxide in a sealed tube using a monomodal microwave synthesiser. These rapid and efficient methods often require no chromatographic purification and so are appropriate for ...

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