Tetrahedron

Intramolecular cyanoamidation of unsaturated cyanoformamides catalyzed by palladium: an efficient synthesis of multi-functionalized lactams

Y Kobayashi, H Kamisaki, H Takeda, Y Yasui…

Index: Kobayashi, Yusuke; Kamisaki, Haruhi; Takeda, Hiroshi; Yasui, Yoshizumi; Yanada, Reiko; Takemoto, Yoshiji Tetrahedron, 2007 , vol. 63, # 14 p. 2978 - 2989

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Citation Number: 67

Abstract

The Pd (0)-catalyzed intramolecular cyanoamidation of several unsaturated cyanoformamides with alkenyl, allenyl, and alkynyl groups was investigated. In the cases of alkynyl and 1, 1-disubstituted alkenyl cyanoformamides, the Pd (0)-catalyzed C–CN activation and subsequent insertion reaction proceeded smoothly and gave the corresponding lactams bearing a cyano group at the β-position in good yields. The ...