Semisynthetische Myxovirescine: Austausch des α??Hydroxycarbonsäure??Segments und Modifikation der Ringgröße

K Borgschulte, W Trowitzsch??Kienast…

Index: Borgschulte, Katrin; Trowitzsch-Kienast, Wolfram; Hoefle, Gerhard Liebigs Annalen der Chemie, 1990 , # 1 p. 69 - 81

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Citation Number: 5

Abstract

Partial degradation reactions of the macrocyclic lactam-lacton antibiotic myxovirescin Al (1) yield the key building blocks 2 and 26. From these myxovirescin analoga are reconstituted with various alkyl groups at position C-2 with R and S configuration. Furthermore a ring- contracted (24) and a ringenlarged (29) macrocycle are synthesized. The growth of E. coli is best inhibited by the natural myxovirescin Al with a (2s) propyl substitution whilst 24 and ...