Organic letters

Ethyl cyanoacetate: a new cyanating agent for the palladium-catalyzed cyanation of aryl halides

S Zheng, C Yu, Z Shen

Index: Zheng, Shuyan; Yu, Chunhui; Shen, Zhengwu Organic Letters, 2012 , vol. 14, # 14 p. 3644 - 3647

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Citation Number: 42

Abstract

Many methods have been developed to introduce cyano groups into molecules. The traditional approaches for the preparation of aryl nitriles(1, 3)involve the Rosenmund–von Braun reaction from the corresponding halides or the Sandmeyer reaction from aniline. In an industrial setting, the ammoxidation reaction is typically used.(4) Recently, a useful alternative for the preparation of aryl nitriles was developed using transition-metal-catalyzed cyanation of aryl-X ...

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