Tetrahedron Letters

Controlled conversion of phenylacetic acids to phenylacetonitriles or benzonitriles using bis (2-methoxyethyl) aminosulfur trifluoride

CO Kangani, BW Day, DE Kelley

Index: Kangani, Cyrous O.; Day, Billy W.; Kelley, David E. Tetrahedron Letters, 2008 , vol. 49, # 5 p. 914 - 918

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Citation Number: 25

Abstract

A mild, efficient, and practical method for the one-step synthesis of benzonitriles from phenylacetic acids using bis (2-methoxyethyl) aminosulfur trifluoride is described. The reaction was easily extended to the synthesis of the corresponding phenylacetonitriles by inclusion of triethylphosphine.

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