Substituted methyl groups: Substituent effects

WA Sheppard

Index: Sheppard,W.A. Tetrahedron, 1971 , vol. 27, p. 945 - 951

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Citation Number: 30

Abstract

The substituent parameters for the series of mono-, di-and trisubstituted Me groups, CH2X, CHX2, and CX3 where X is F, Cl, Br, OMe, SCF3 and CN, have been determined from F19 NMR measurements on the corresponding meta-and para-fluorotoluenes. An additive linear effect of substitution is found only for the cyano substituent. A saturation effect noted for the groups where X is F, Cl, Br and SCF3 (particularly chloro and bromo) after disubstitution is ...