PPL-catalyzed resolution of 1, 2-and 1, 3-diols in methyl propionate as solvent. An application of the tandem use of enzymes.

AJM Janssen, B Zwanenburg

Index: Janssen, A. J. M.; Klunder, A, J. H.; Zwanenburg, B. Tetrahedron, 1991 , vol. 47, # 35 p. 7409 - 7416

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Citation Number: 44

Abstract

The Porcine Pancreatic Lipase (PPL)-catalyzed transesterification of 1-phenyl-1, 2- ethanediol 1, 2-phenyl-1, 2-propanediol 2 1, 2-decanediol 3 1, 2-pentanediol 4 1, 2- butanediol 5 1, 2-propanediol 6 and 1, 3-butanediol 7 in methyl propionate as solvent was evaluated. In alt substrates the primary hydroxy group is esterified exclusively. The enantioselectivity displayed in this PPL-catalyzed reaction is moderate. The enantiomeric ...