Helvetica chimica acta

Solid??Phase Synthesis of Dipeptide??Conjugated Nucleosides and Their Interaction with RNA

G Dong, L Zhang, L Zhang

Index: Dong, Guimin; Zhang, Liangren; Zhang, Lihe Helvetica Chimica Acta, 2003 , vol. 86, # 10 p. 3516 - 3524

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Citation Number: 7

Abstract

Abstract Dipeptide-conjugated nucleosides were efficiently synthesized from the intermediates of 3′-amino-3′-deoxy-nucleosides by using the solid-phase synthetic strategy with HOBt/HBTU (1-hydroxy-1H-benzotriazole/2-(1H-benzotriazol-1-yl)-1, 1, 3, 3- tetramethyluronium hexafluoroborate) as the coupling reagents (Schemes 1–3). CD Spectra and thermal melting studies showed that the synthesized hydrophobic dipeptide [BOND] ...

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